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Abstract
Advances in Complementary & Alternative medicine
Cannabinoids: Pivotal Role in Sepsis
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Open or ClosePreeti Singh*
College of Veterinary Science and Animal Husbandry, India
*Corresponding author: Preeti Singh, College of Veterinary Science and Animal Husbandary, DUVASU, Mathura, India
Submission: August 17, 2018; Published: January 18, 2019
ISSN: 2637-7802Volume3 Issue4
Abstract
Sepsis is a multifactorial disease with uncontrolled systemic production of inflammatory mediators (‘cytokine storm’) leading to systemic inflammatory response syndrome (SIRS) following microbial infection. It is characterized by vascular hyporeactivity, decreased tissue perfusion, tachypnoea, hyperthermia, systemic hypotension, multiorgans failure despite of antibiotic therapy, adequate fluid resuscitation and administration of vasopressors. Infections caused by bacteria (Gram +ve or Gram -ve), fungi, virus, parasites etc. or pathological conditions like ischaemia, burn, abdominal surgery, pancreatitis, haemorrhage etc. favour the developement of niche for sepsis.
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